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Repetitive Transcranial Magnetic Stimulation as an Augmentative Strategy for Treatment-resistant Depression

Background Dozens of randomized controlled trials (RCTs) and meta-analyses have demonstrated the efficacy of repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) treatment, but there has not been a meta-analysis report which evaluates the efficacy and tolerability of rTMS used as an augmentative strategy for antidepressants in treatment-resistant depression (TRD) treatment.

rTMS Induced Tinnitus Relief Is Related to an Increase in Auditory Cortical Alpha Activity

Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show tinnitus relief after rTMS, however effects are moderate and vary strongly across patients.

Recent Advances in Stroke Recovery and Rehabilitation

Several methods, including bedside motor assessment, electrophysiological assessment (by transcranial magnetic stimulation [TMS] to induce motor evoked potential on the unaffected limb), and advanced imaging tools (functional magnetic resonance imaging [MRI] to detect the brain activation pattern) were all found to have some predictive value for motor impairment.

A Journey of Tinnitus

Tinnitus is one of the most common neurological symptoms. Approximately, one-third adults experience it once in their life time, 10% of them experience prolonged tinnitus and 5% suffer from severely disturbing tinnitus.

Response to TMS Sustained in Depression

The final analysis of a study evaluating transcranial magnetic stimulation (TMS) confirms that the majority of patients with resistant depression who respond to TMS in the acute setting continue to have a sustained response for a period of 1 year, an observational trial shows.