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Subthreshold Stimulation Intensity Is Associated With Greater Clinical Efficacy Of Intermittent Theta-burst Stimulation Priming for Major Depressive Disorder

By Jonathan C. Lee, Juliana Corlier, Andrew C. Wilson, Reza Tadayonnejad, Katharine G. Marder, Doan Ngo, David E. Krantz, Scott A. Wilke, Jennifer G. Levitt, Nathaniel D. Ginder, Andrew F. Leuchter

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Intermittent theta-burst stimulation priming (iTBS-P) can improve clinical outcome of patients with Major Depressive Disorder (MDD) who do not show early benefit from 10 Hz stimulation of left dorsolateral prefrontal cortex (DLPFC), also known as high-frequency left-sided (HFL) stimulation. The intensity and pulse number for iTBS-P needed to induce clinical benefit have not been systematically examined.

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