Personalizing rTMS Parameters For Depression Treatment Using Multimodal Neuroimaging
D C W Klooster, M A Ferguson, P A J M Boon, C Baeken
Repetitive transcranial magnetic stimulation (rTMS) is a tool that can be used to administer treatment to neuropsychiatric disorders such as major depressive disorder (MDD). Though, the clinical efficacy is still rather modest. Overly general stimulation protocols that neither consider patient-specific depression symptomology nor individualized brain characteristics, such as anatomy, or structural and functional connections, may be the cause of the high inter- and intra-individual variability in rTMS clinical responses. Multimodal neuroimaging can provide the necessary insights into individual brain characteristics and can therefore be used to personalize rTMS parameters.