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Research Explores Neurocognitive Profile, Cognitive Impairment in MDD

Study supports evidence for long-term impairment in memory, executive function.

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A literature review provided new insight into the clinical neurocognitive profile in major depressive disorder (MDD) and its relationship to cognitive deficits.

In reviewing and comparing the studies, the investigators noted that the literature supports evidence that individuals with depression may experience: long-term memory impairment, particularly as their age increases; long-term impairment in executive function; attentional deficits, both during depressive episodes and as a residual symptom; and impairments in processing speed, which were reported to be the most pronounced impairments, as well as the most influenced by state, trait, and scar effects.

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