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Large-Scale Analysis of Interindividual Variability in Theta-Burst Stimulation Data: Results From the ‘Big TMS Data Collaboration’

By Daniel T.Corpa, Hannah G.K.Bereznicki, Gillian M.Clark, George J.Youssef, Peter J.Fried, Ali Jannati, Charlotte B.Davie, Joyce Gomes-Osman, Julie Stamm, Sung Wook Chung, Steven J. Bowe, Nigel C.Rogasch, Paul B. Fitzgerald, Giacomo Koch, Vincenzo Di Lazzaro, Alvaro Pascual-Leone, Peter G. Enticott, the ‘Big TMS Data Collaboration’

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Many studies have attempted to identify the sources of interindividual variability in response to theta-burst stimulation (TBS). However, these studies have been limited by small sample sizes, leading to conflicting results. This study brought together over 60 TMS researchers to form the ‘Big TMS Data Collaboration’, and create the largest known sample of individual participant TBS data to date. The goal was to enable a more comprehensive evaluation of factors driving TBS response variability.

118 corresponding authors of TMS studies were emailed and asked to provide deidentified individual TMS data. Mixed-effects regression investigated a range of individual and study level variables for their contribution to variability in response to iTBS and cTBS.

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