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High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Functional Recovery by Enhancing Neurogenesis and Activating BDNF/TrkB Signaling in Ischemic Rats

Repetitive transcranial magnetic stimulation (rTMS) has rapidly become an attractive therapeutic approach for stroke. However, the mechanisms underlying this remain elusive. This study aimed to investigate whether high-frequency rTMS improves functional recovery mediated by enhanced neurogenesis and activation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway and to compare the effect of conventional 20 Hz rTMS and intermittent theta burst stimulation (iTBS) on ischemic rats. Rats after rTMS were sacrificed seven and 14 days after middle cerebral artery occlusion (MCAO), following evaluation of neurological function.

Transcranial DC Stimulation: Ready for Regular Use in Treating Major Depression?

Studies of transcranial direct-current stimulation (tDCS), which is one of several emerging biological nonpharmacologic interventions proposed to treat depression, have had mixed results. Now a team of investigators[1] from the University of São Paulo, Brazil, have undertaken a systematic review and meta-analysis of individual patient data to assess tDCS efficacy and explore individual response predictors.

The impact of cerebellar transcranial direct current stimulation (tDCS)

The cerebellum has been shown to be important for skill learning, including the learning of motor sequences. We investigated whether cerebellar transcranial direct current stimulation (tDCS) would enhance learning of fine motor sequences. Because the ability to generalize or transfer to novel task variations or circumstances is a crucial goal of real world training, we also examined the effect of tDCS on performance of novel sequences after training.

Did You Know There Are 4 Different Types of Depression?

Depression therapies range from lifestyle methods such as talk therapy and exercise, medicinal treatments such as prescription antidepressants, medical treatments such as transcranial magnetic stimulation or, in particularly tough cases, electroshock therapy. Up until now, deciding which therapies would work best for which patient has been a matter of trial and error, but this new Cornell research will help doctors match the type of depression someone has to the best treatment for that version specifically.

Brain stimulation guides people through an invisible maze

You’re stuck in a maze. You can’t see the walls, or the floor. All you have to navigate is a device on your head stimulating your brain to tell you which way to go. In an experiment at the University of Washington in Seattle, participants solved a maze puzzle guided only by transcranial magnetic stimulation (TMS). The findings suggest that this type of brain prompt could be used to augment virtual reality experiences or help give people who are blind “visual” information about their surroundings.

Transcranial direct current stimulation shows promise for depression therapy

Small amounts of electricity similar to the output of a common 9-volt battery could improve life for people living with major depression, the most common mood disorder. A new study at the University of Kansas will investigate the potential of transcranial direct current stimulation, or tDCS, whereby a safe, low current of electricity is applied to the brain by placing electrodes on a person's scalp. The painless technique may be a useful as a therapy for depression, especially in conjunction with antidepressant medications.

Self-Control Isn’t Just Controlling Impulses, but Also Changing Perspective

This theory was tested using transcranial magnetic stimulation to disrupt the function of the pTPJ in two separate studies on volunteer subjects from the University of Zurich. The disruption of this subregion of the brain would ultimately indicate if the subjects still held their capacity of self-control or if they became selfish and impulsive. The first study investigated 43 subjects who performed two tasks.